Publication
2024
Original Article
Sakata K, Kioka N, Ueda K, Kimura Y.
The ATPase activity of ABCA1 is increased by cholesterol in the presence of anionic lipids.
J Biochem. 10.1093/jb/mvae003.(2024)
2023
Original Article
Tachibana H, Minoura K, Omachi T, Nagao K, Ichikawa T, Kimura Y, Kono N, Shimanaka Y, Arai H, Ueda K, Kioka N.
The plasma membrane of focal adhesions has a high content of cholesterol and phosphatidylcholine with saturated acyl chains.
J Cell Sci. 10.1242/jcs.260763.(2023)
Futamata R, Kinoshita M, Ogiwara K, Kioka N, Ueda K.
Cholesterol accumulation in ovarian follicles causes ovulation defects in Abca1a−/− Japanese medaka (Oryzias latipes).
Heliyon. 10.1016/j.heliyon.2023.e13291.(2023)
Reviews
黒田美都、木岡紀幸
力学刺激の感知における細胞骨格関連タンパク質の機能
SORBSタンパク質による間葉系幹細胞分化の調節
化学と生物61, 408-409.(2023)
2021
Original Articles
Nakato M, Shiranaga N, Tomioka M, Watanabe H, Kurisu J, Kengaku M, Komura N, Ando H, Kimura Y, Kioka N and Ueda K.
ABCA13 dysfunction associated with psychiatric disorders causes impaired cholesterol trafficking.
J Biol Chem. In press
Protocol
Futamata R. Kioka N and Ueda K.
Live Cell FRET Analysis of the Conformational Changes of Human P-glycoprotein.
bio-protocol. 11(4):e3930.(2021)
2020
Original Articles
Murakami Y, Futamata R, Horibe T, Ueda K, Kinoshita M.
CRISPR/Cas9 nickase-mediated efficient and seamless knock-in of lethal genes in the medaka fish Oryzias latipes.
Dev Growth Differ. 62(9):554-567.(2020)
Takata K, Goto T, Kuroda M, Kimura Y, Harada I, Ueda K, Kawada T, Kioka N.
Stiffness of the extracellular matrix regulates differentiation into beige adipocytes.
Biochem Biophys Res Commun. 532(2):205-210.(2020)
Futamata R, Ogasawara F, Ichikawa T, Kodan A, Kimura Y, Kioka N, Ueda K.
In vivo FRET analyses reveal a role of ATP hydrolysis-associated conformational changes in human P-glycoprotein.
J Biol Chem. 295, 5002-5011.(2020)
Okamoto Y, Tomioka M, Ogasawara F, Nagaiwa K, Kimura Y, Kioka N, Ueda K.
C-terminal of ABCA1 separately regulates cholesterol floppase activity and cholesterol efflux activity.
Biosci Biotechnol Biochem. 84(4):764-773.(2020)
Reviews
Kodan A, Futamata R, Kimura Y, Kioka N, Nakatsu T, Kato H, Ueda K.
ABCB1/MDR1/P-gp employs an ATP-dependent twist-and-squeeze mechanism to export hydrophobic drugs
FEBS Letters. In Press
2019
Original Articles
Watanabe T, Kioka N, Ueda K, Matsuo M.
Phosphorylation by protein kinase C stabilizes ABCG1 and increases cholesterol efflux.
J Biochem. (2019)
Hara A, Kobayashi H, Asai N, Saito S, Higuchi T, Kato K, Okumura T,Bando YK, Takefuji M, Mizutani Y, Miyai Y, Saito S, Maruyama S, Maeda K,Ouchi N, Nagasaka A, Miyata T, Mii S, Kioka N, Worthley DL, Murohara T,Takahashi M, Enomoto A.
Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction.
Circ Res. 125(4):414-430.(2019)
Fumihiko Ogasawara, Fumi Kano, Masayuki Murata, Yasuhisa Kimura, Noriyuki Kioka and Kazumitsu Ueda.
Changes in the asymmetric distribution of cholesterol in the plasma membrane influence streptolysin O pore formation.
Sci Rep. 10.1038/s41598-019-39973-x.(2019)
Atsushi Kodan, Tomohiro Yamaguchi, Toru Nakatsu, Keita Matsuoka, Yasuhisa Kimura, Kazumitsu Ueda and Hiroaki Kato.
Inward- and outward-facing X-ray crystal structures of homodimeric P-glycoprotein CmABCB1.
Nature Commun. 10.1038/s41467-018-08007-x.(2019)
Reviews
木岡紀幸
細胞-細胞外マトリックス間接着のメカノセンサー
生体の科学 70(4):290-295(2019)
出口真次、松井翼、市川尚文、木岡紀幸
細胞収縮力アッセイ
細胞 51(3):140-143(2019)
2018
Original Ariticles
Naoya Hino, Tkafumi Ichikawa, Yasuhisa Kimura, Michiyui Matsuda, Kazumitsu Ueda and Noriyuki Kioka
An amphipathic helix of vinexine alpha is necessary for substrate stiffness-dependent conformational change in vinculin.
J Cell Sci 10.1242/jcs.217349. (2018)
Takaaki Kawanobe,Naoko Shiranaga, Noriyuki Kioka, Yasuhisa Kimura and Kazumitsu Ueda
Apolipoprotein A-I directly interacts with extracellular domain 1 of human ABCA1.
Biosci Biotechnol Biochem 10.1080/09168451.2018.1547106. (2018)
Shiho Ito, Noriyuki Kioka and Kazumitsu Ueda
Cell migration is negatively modulated by ABCA1.
Biosci Biotechnol Biochem 10.1080/09168451.2018.1547105. (2018)
Mito Kuroda, Kazumitsu Ueda and Noriyuki Kioka
Vinexin family (SORBS) proteins regulate mechanotransduction in mesenchymal stem cells.
Sci Rep. 8:11581(2018)
Masato Ishigami, Fumihiko Ogasawara, Kohjiro Nagao, Hidehiko Hashimoto, Yasuhisa Kimura, Noriyuki Kioka and Kazumitsu Ueda
Temporary sequestration of cholesterol and phosphatidylcholine within extracellular domain of ABCA1 during nascent HDL generation.
Sci Rep. 8:6170(2018)
Ana Perea, Jose IgnacioManzano, Yasuhisa Kimura, Kazumitsu Ueda, Santiago Castanys and Francisco Gamarro
Leishmania LABCG2 transporter is involved in ATP-dependent transport of thiols.
Biochem J. 475, 87-97(2018)
Reviews
出口真次、松井翼、市川尚文、木岡紀幸
細胞収縮力のアッセイ-メカノバイオロジー研究のツール
Precision Medicine 1, 108-111(2018)
植田和光
過剰なコレステロールは、なぜ健康にとってよくないのか？
化学と生物 56, 165-170(2018)
2017
Original Articles
Fukuda S. P., Matsui T.S., Ichikawa T, Furukawa T, Kioka N, Fukushima S, Deguchi S.
Cellular force assay detects altered contractility caused by a nephritis-associated mutation in nonmuscle myosin ⅡA.
Dev Growth Differ 59, 423-433.(2017)
Fukada T, Sakajiri H, Kuroda M, Kioka N, Sugimoto K.
Fluid shear stress applied by orbital shaking induces MG-63 osteosarcoma cells to activate ERK in two phases through distinct signaling pathways.
Biochemistry and Biophysics Reports. 9, 257-265(2017)
Takafumi Ichikawa, Masahiro Kita, Tsubasa S. Matsui, Ayaka Ichikawa Nagasato, Tomohiko Araki, Shian-Huey Chiang, Takuhito Sezaki, Yasuhisa Kimura, Kazumitsu Ueda, Shinji Deguchi, Alan R. Saltiel, and Noriyuki Kioka.
Vinexin family (SORBS) proteins play different roles in stiffness-sensing and contractile force generation.
J Cell Sci 130, 3517-3531(2017)
Maiko Tomioka, Yoshinobu Toda, Noralyn B. Manucat, Hiroyasu Akatsu, Manabu Fukumoto, Nozomu Kono, Hiroyuki Arai, Noriyuki Kioka, and Kazumitsu Ueda.
Lysophosphatidylcholine export by human ABCA7.
Biochim Biophys Acta 1862, 658-665 (2017)
Tomohiro Omachi, Takafumi Ichikawa, Yasuhisa Kimura, Kazumitsu Ueda, and Noriyuki Kioka.
Vinculin Association with Actin Cytoskeleton is Necessary for Stiffness-dependent Regulation of Vinculin Behavior.
PLos One 12, e0175324 (2017)
Ayaka Ichikawa Nagasato, Hiroshi Yamashita, Michinori Matsuo, Kazumitsu Ueda and Noriyuki Kioka.
The distribution of vinculin to lipid rafts plays an important role in sensing stiffness of extracellular matrix.
Biosci Biotechnol Biochem 81, 1136-1147 (2017)
Mito Kuroda, Hiroki Wada, Yasuhisa Kimura, Kazumitsu Ueda and Noriyuki Kioka.
Vinculin promotes nuclear localization of TAZ to inhibit ECM stiffness-dependent differentiation into adipocytes.
J Cell Sci 130, 989-1002 (2017)
Shu-Lin Liu, Ren Sheng, Jae Hun Jung, Li Wang, Ewa Stec, Matthew J O’Connor, Seohyoen Song, Rama Kamesh Bikkavilli, Robert A Winn, Daesung Lee, Kwanghee Baek, Kazumitsu Ueda, Irena Levitan, Kwang-Pyo Kim and Wonhwa Cho.
Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol.
Nature Chem Biol 13, 268-274 (2017)
Reviews
Kazumitsu Ueda.
Celebrating Dr. Satoshi Omura, the Recipient of the 2015 Nobel Prize in Physiology or Medicine -Agricultural chemistry, ivermectin, and MDR1.
Biosci Biotechnol Biochem 81, 1-2 (2017)
2016
Original Article
Osamu Sano, Maki Tsujita, Yuuji Shimizu, Reiko Kato, Aya Kobayashi, Noriyuki Kioka, Alan T Remaley, Makoto Michikawa, Kazumitsu Ueda, and Michinori Matsuo.
ABCG1 and ABCG4 Suppress γ-Secretase Activity and Amyloid β Production.
PLoS One. 11(5):e0155400 (2016)
Ken-ichi Miyata, Yoshiaki Nakagawa, Yasuhisa Kimura, Kazumitsu Ueda, and Miki Akamatsu
In vitro and in vivo evaluations of the P-glycoprotein-mediated efflux of dibenzoylhydrazines.
Toxicol Appl Pharmacol. 298, 40-47 (2016)
Reviews
永田紅
ABCA1によるHDL産生機構～１分子イメージングによる解析
膜(MEMBRANE) 41(5)，221-225(2016)
2015
Original Articles
Lucia Tomiyama, Takuhito Sezaki, Michinori Matsuo, Kazumitsu Ueda, and Noriyuki Kioka
Loss of Dlg5 expression promotes the migration and invasion of prostate cancer cells via Girdin phosphorylation.
Oncogene 24, 1141-1149 (2015)
Yu Zhao, Masato Ishigami, Kohjiro Nagao, Kentaro Hanada, Nozomu Kono, Hiroyuki Arai, Michinori Matsuo, Noriyuki Kioka and Kazumitsu Ueda
ABCB4 exports phosphatidylcholine in a sphingomyelin-dependent manner.
J Lipid Res. 56, 644-652 (2015)
Shimpei Itoh, Kohjiro Nagao, Yasuhisa Kimura, Michinori Matsuo, Noriyuki Kioka, and Kazumitsu Ueda
Position 834 in TM6 plays an important role in cholesterol and phosphatidylcholine transport by ABCA1.
Biosci Biotechnol Biochem. 10.1080/09168451.2014.993358.(2015)
2014
Original Articles
Tomohiro Chiba, Tsuyoshi Sakurada, Rie Watanabe, Kohji Yamaguchi, Yasuhisa Kimura, Noriyuki Kioka, Hirokazu Kawagishi, Michinori Matsuo, Kazumitsu Ueda
Fomiroid A, a novel compound from the mushroom Fomitopsis nigra, inhibits NPC1L1-mediated cholesterol uptake via a mode of action distinct from that of ezetimibe.
PLoS One. 9(12):e116162 (2014)
Ting-Fang Kuo, Di Mao, Nao Hirata, Bilon Khambu, Yasuhisa Kimura, Eihachiro Kawase, Hiroki Shimogawa, Makoto Ojika, Norio Nakatsuji, Kazumitsu Ueda, and Motonari Uesugi
Selective elimination of human pluripotent stem cells by a marine natural product derivative.
J Am Chem Soc. 136, 9798-801 (2014)
Osamu Sano, Shiho Ito, Reiko Kato, Yuji Shimizu, Aya Kobayashi, Yasuhisa Kimura, Noriyuki Kioka, Kentaro Hanada, Kazumitsu Ueda, and Michinori Matsuo
ABCA1, ABCG1, and ABCG4 are distributed to distinct membrane meso-domains and disturb detergent-resistant domains on the plasma membrane
PLoS One. 9(10):e109886 (2014)
Risa Omura, Kohjiro Nagao, Norihiro Kobayashi, Kazumitsu Ueda, and Hiroyuki Saito
Direct detection of ABCA1-dependent HDL formation based on lipidation-induced hydrophobicity change in apoA-I.
J Lipid Res. 55, 2423-2431 (2014)
Atsushi Kodan, Tomohiro Yamaguchi, Toru Nakatsu, Keita Sakiyama, Christopher J. Hipolito, Akane Fujioka, Ryo Hirokane, Keiji Ikeguchi, Bunta Watanabe, Jun Hiratake, Yasuhisa Kimura, Hiroaki Suga, Kazumitsu Ueda, Hiroaki Kato
Structural Basis for Gating Mechanisms of a Eukaryotic P-glycoprotein Homolog.
Proc Natl Acad Sci U S A. 111, 4049-4054 (2014)
Hiroshi Yamashita*, Takafumi Ichikawa*, Daisuke Matsuyama, Yasuhisa Kimura, Kazumitsu Ueda, Susan W. Craig, Ichiro Harada, and Noriyuki Kioka
The role of the interaction of the vinculin proline-rich linker region with vinexin α in sensing the stiffness of the extracellular matrix.
J.Cell Sci. 127, 1875-1886 (2014)
*equally contributed to this work
Nao Hirata*, Masato Nakagawa*, Yuto Fujibayashi*, Kaori Yamauchi*, AsakoMurata, Itsunari Minami, Maiko Tomioka, Takayuki Kondo, Ting-Fang Kuo, Hiroshi Endo, Haruhisa Inoue, Shin-ichi Sato, Shin Ando, Yoshinori Kawazoe, Kazuhiro Aiba, Koh Nagata, Eihachiro Kawase, Young-Tae Chang, Hirofumi Suemori, Koji Eto, Hiromitsu Nakauchi, Shinya Yamanaka, Norio Nakatsuji, Kazumitsu Ueda, Motonari Uesugi
A Chemical Probe Selective for Human Pluripotent Stem Cells.
Cell Reports 6, 1165-1174 (2014)
*equally contributed to this work
Reviews
石神正登、植田和光
善玉コレステロール産生の初期段階の可視化
Bio Industry. 31, 41-46 (2014)
植田和光、冨岡麻衣子
膜脂質輸送にかかわるABC蛋白質
医学のあゆみ. 248, 1151-1165 (2014)
木村泰久
脂質輸送型ABCタンパク質の基質認識、輸送機構
膜(MEMBRANE). 39. 68-73 (2014)
2013
Original Articles
Shigenobu Kishino, Michiki Takeuchi, Si-Bum Park, Akiko Hirata, Nahoko Kitamura, Jun Kunisawa, Hiroshi Kiyonod, Ryo Iwamoto, Yosuke Isobe, Makoto Arita, Hiroyuki Arai, Kazumitsu Ueda, Jun Shima, Satomi Takahashi, Kenzo Yokozeki, Sakayu Shimizu, and Jun Ogawa
Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition.
Proc Natl Acad Sci U S A. 110(44), 17808-17813 (2013)
Satoshi Kanaoka, Yasuhisa Kimura, Masaaki Fujikawa, Yoshiaki Nakagawa, Kazumitsu Ueda and Miki Akamatsu
Substrate recognition by P-glycoprotein efflux transporters: Structure-ATPase activity relationship of diverse chemicals and agrochemicals.
J. Pestic. Sci. 38(3), 112-122 (2013)
Naohiro Takemoto, Tetsuya Suehara, Heidie L. Frisco, Shin-ichi Sato, Takuhito Sezaki, Kosuke Kusamori, Yoshinori Kawazoe, Sun Min Park, Sayumi Yamazoe, Yoshiyuki Mizuhata, Rintaro Inoue, Miller GJ, Hansen SU, Jayson GC, Gardiner JM, Toshiji Kanaya, Norihiro Tokitoh, Kazumitsu Ueda, Yoshinobu Takakura, Noriyuki Kioka, Makiya Nishikawa, and Motonari Uesugi
Small-Molecule-Induced Clustering of Heparan Sulfate Promotes Cell Adhesion.
J Am Chem Soc. 135, 11032-11039 (2013)
Akihiro Matsuda, Kohjiro Nagao, Michinori Matsuo, Noriyuki Kioka and Kazumitsu Ueda
24(S)-hydroxycholesterol is actively eliminated from neuronal cells by ABCA1.
J. Neurochem 126, 93-101, 20135(2013)
Takuhito Sezaki, Lucia Tomiyama, Yasuhisa Kimura, Kazumitsu Ueda and Noriyuki Kioka
Dlg5 interacts with TGF-receptor and promotes its degradation.
FEBS Lett 587, 1624-1629 (2013)
Koh O. Nagata, Chieko Nakada, Rinshi Kasai, Akihiro Kusumi and Kazumitsu Ueda
ABCA1 dimer-monomer interconversion during HDL generation revealed by single-molecule imaging.
Proc. Natl. Acad. Sci. USA, 110(13):5034-9(2013)
Masato Ishigami, Yuko Tominaga, Kohjiro Nagao, Yasuhisa Kimura, Michinori Matsuo, Noriyuki Kioka and Kazumitsu Ueda
ATPase activity of nucleotide binding domains of human MDR3 in the context of MDR1
Biochim Biophys Acta 1831(4):683-90(2013)
Hiroshi Hirayama, Yasuhisa Kimura, Noriyuki Kioka, Michinori Matsuo, and Kazumitsu Ueda
ATPase activity of human ABCG1 is stimulated by cholesterol and sphingomyelin
J. Lipid Res. 54, 496-502 (2013)
Kohjiro Nagao, Minami Maeda, Noralyn B. Manucat and Kazumitsu Ueda
Cyclosporine A and PSC833 inhibit ABCA1 function via direct binding
Biochim Biophys Acta 1831, 398-406 (2013)
2012
Original Articles
Maiko TOMIOKA, Yoshinobu TODA, Junko KURISU, Yasuhisa KIMURA, Mineko KENGAKU, and Kazumitsu UEDA
The Effects of Neurological Disorder-Related Codon Variations of ABCA13 on the Function of the ABC Protein
Biosci. Biotechnol. Biochem. 76 (12), 12563-1-5 (2012)
Sabine Hulpke, Maiko Tomioka, Elisabeth Kremmer, Kazumitsu Ueda, Rupert Abele and Robert Tampe
Direct evidence that the N-terminal extensions of the TAP complex act as autonomous interaction scaffolds for the assembly of the MHC I peptide-loading complex
Cell Mol Life Sci. 69, 3317 3327 (2012)
Takuhito Sezaki, Kohki Inada, Takayuki Sogabe, Kumiyo Kakuda, Lucia Tomiyama, Yohsuke Matsuno, Takafumi Ichikawa, Michinori Matsuo, Kazumitsu Ueda, and Noriyuki Kioka
Role of Dlg5/lp-dlg, a membrane-associated guanylate kinase family protein, in epithelial-mesenchymal transition in LLc-PK1 renal epithelial cells
PLoS ONE 7(4): e35519 (2012)
Kohjiro Nagao, Kei Takahashi, Yuya Azuma, Mie Takada, Yasuhisa Kimura, Michinori Matsuo, Noriyuki Kioka, and Kazumitsu Ueda
ATP hydrolysis-dependent conformational changes in the extracellular domain of ABCA1 are associated with apoA-I binding
J. Lipid Res. 53(1):126-36 (2012)
Nagao, K., Kimura, Y. and and Ueda, K.
Lysine residues of ABCA1 are required for the interaction with apoA-I.
Biochim Biophys Acta 1821(3):530-5 (2012)
Reviews
長尾耕治郎、植田和光
ABCA1によるコレステロール恒常性制御
細胞工学 Vol.31 No.5 535-40(2012)
2011
Original Articles
Hozoji-Inada, M., Munehira, Y., Nagao, K., Kioka, N., and Ueda, K.
LXRb directly interacts with ABCA1 to promote HDL formation during acute cholesterol accumulation.
J. Biol. Chem. 286, 20117-24 (2011)
Hiroshi Yamashita, Kazumitsu Ueda, Noriyuki Kioka
WAVE2 forms a complex with cAMP-dependent protein kinase (PKA) and is involved in PKA enhancement of membrane protrusions
J. Biol. Chem. 286, 3907-3914 (2011)
Matsuo M, Campenot RB, Vance DE, Ueda K, Vance JE.
Involvement of low-density lipoprotein receptor-related protein and ABCG1 in stimulation of axonal extension by apoE-containing lipoproteins
Biochim Biophys Acta. 1811, 31-38 (2011)
Reviews
Nagao, K., Hozoji-Inada, M., Azuma, Y., and Ueda, K.
ABCA1-Mediated HDL Formation: Mechanism and Regulation in “The ABC transporters of human physiology and disease”
ed by Linton, K. and Holland, IB. World Scientific Publishing Co. 10.11429789814280075_0002 (2011)
Nagao, K., Tomioka, M., and Ueda, K
Function and regulation of ABCA1- Membrane meso-domain organization and re-organization
FEBS J 278(18), 3190-203 (2011)
Ueda, K.
ABC proteins protect human body and maintain optimal health
Biosci Biotechnol Biochem 75, 401-409 (2011)
2010
Original Articles
Terakado, K., Kodan, A., Nakano, N., Kimura, Y., Ueda, K., Nakatsu, T., and Kato, H.
Deleting two C-terminal alpha-helices is effective to crystallize the bacterial ABC transporter Escherichia coli MsbA complexed with AMP-PNP
Acta Cryst D66, 319-323 (2010)
Yamazaki T, Fujiwara N, Yukinaga H, Ebisuya M, Shiki T, Kurihara T, Kioka N, Kambe T, Nagao M, Nishida E, Masuda S.
The closely related RNA helicases, UAP56 and URH49, preferentially form distinct mRNA export machineries and coordinately regulate mitotic progression.
Mol Biol Cell 21; 2953-2965 (2010)
Shichiri M, Takanezawa Y, Rotzoll DE, Yoshida Y, Kokubu T, Ueda K, Tamai H, Arai H.
ATP-Binding cassette transporter A1 is involved in hepatic alpha-tocopherol secretion.
J Nutr Biochem. 21, 451-456 (2010)
Noriyuki Kioka, Takuya Ito, Hiroshi Yamashita,Natsuko Uekawa, Tsutomu Umemoto, Soh Motoyoshi, Hiroshi Imai, Kenzo Takahashi, Hideto Watanabe, Masayasu Yamada, Kazumitsu Ueda
Crucial role of vinexin for keratinocyte migration in vitro and epidermal wound healing in vivo
Exp. Cell Res. 316(10), 1728-1738 (2010)
Reviews
Kohjiro Nagao, Yasuhisa Kimura, Michinori Mastuo, Kazumitsu Ueda
Lipid outward translocation by ABC proteins
FEBS Letters 584(13), 2717-2723 (2010)